Baker Lab 2016
2012 Baker Lab
Mortar and pestle work, in the lab
Baker Lab 2010
Barbara Baker


Baker Lab Research on Plant Innate Immunity

Nicotiana benthamiana infected with tobacco mosaic virus (TMV) expressing the green fluorescent protein (GFP). TMV-GFP infection and spread is detected under UV light.Our research focuses on understanding molecular-genetic mechanisms of plant innate immunity. We are investigating the structure, function and evolution of host genes for pathogen disease resistance. Our experimental system includes viral, bacterial and oomycete plant pathogens and their Solanaceae plant hosts. We anticipate that our studies will lead to new environmentally benign strategies for durable, broad-spectrum disease resistant crops. 

SoMART Webserver for miRNA & siRNA Analysis

We designed the SoMART webserver with a suite of bioinformatic tools and sequence databases for discovery and analyses of miRNAs and siRNAs that regulate plant genes of interest.

Innovative Genomics Institute (IGI) 2017 award for research on plant innnate immunity

Barbara Baker and Jacob Brunkard received an Innovative Genomics Institute (IGI) 2017 award for research on DCL4 regulation of plant innate immunity.

MicroRNA regulation of plant innate immune receptors

Plant innate immunity depends on recognition of pathogen effectors and triggering of host defenses. Plant resistance (R)-genes encode a major class of innate immune receptors. Plant microRNAs (miRNAs) and small interfering RNAs (siRNAs) guide gene silencing and play essential regulatory roles in development, genome function and host defense. We discovered novel miRNA families whose members silence R-genes including those encoding resistance to major pathogens of Solanaceae crops.
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