University of California, Berkeley | Plant & Microbial Biology
Conserved transcription factors NRZ1 and NRM1 regulate NLR receptor-mediated immunity.
| Title | Conserved transcription factors NRZ1 and NRM1 regulate NLR receptor-mediated immunity. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Zhang Q, Wang J, Li Y, Tung J, Deng Y, Baker B, Dinesh-Kumar SP, Li F |
| Journal | Plant Physiol |
| Volume | 195 |
| Issue | 1 |
| Pagination | 832-849 |
| Date Published | 2024 Apr 30 |
| ISSN | 1532-2548 |
| Keywords | Arabidopsis, Arabidopsis Proteins, Cell Death, Gene Expression Regulation, Plant, NLR Proteins, Plant Diseases, Plant Immunity, Signal Transduction, Transcription Factors |
| Abstract | <p>Plant innate immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) class of immune receptors plays an important role in defense against various pathogens. Although key biochemical events involving NLR activation and signaling have been recently uncovered, we know very little about the transcriptional regulation of NLRs and their downstream signaling components. Here, we show that the Toll-Interleukin 1 receptor homology domain containing NLR (TNL) gene N (Necrosis), which confers resistance to Tobacco mosaic virus, is transcriptionally induced upon immune activation. We identified two conserved transcription factors, N required C3H zinc finger 1 (NRZ1) and N required MYB-like transcription factor 1 (NRM1), that activate N in an immune responsive manner. Genetic analyses indicated that NRZ1 and NRM1 positively regulate coiled-coil domain-containing NLR- and TNL-mediated immunity and function independently of the signaling component Enhanced Disease Susceptibility 1. Furthermore, NRZ1 functions upstream of NRM1 in cell death signaling, and their gene overexpression induces ectopic cell death and expression of NLR signaling components. Our findings uncovered a conserved transcriptional regulatory network that is central to NLR-mediated cell death and immune signaling in plants.</p> |
| DOI | 10.1093/plphys/kiae054 |
| Alternate Journal | Plant Physiol |
| PubMed ID | 38306630 |
| Grant List | 32272491 / / National Natural Science Foundation of China / CARS-23-A13 / / Earmarked fund / IOS-1354434 / / National Science Foundation / 2030-22000-009-00D / / USDA ARS / / / Innovative Genomics Institute 2017 Award / |